If you are interested in learning more about the next-generation sequencing technologies, i.e., 454, Solexa (Illumina), and AB SOLiD, you can get a quick overview from a recent article by Elaine Mardis in Trends in Genetics entitled The impact of next-generation sequencing technology on genetics. There is also a companion paper focusing on the ramifications of next-generation sequencing on informatics by Mihai Pop and Steven Salzberg entitled Bioinformatics challenges of new sequencing technology.