A significant amount of effort in genomics over the past year has focused on cancer-related sequencing. However, as a recent story on the role of genetics in schizophrenia demonstrates, there are many conditions that have a devastating impact on human health that, if not diseases of the genome, are greatly affected by an individual's genome. The 1000 Genomes Project will lay a significant foundation for studying the role of the genome in such conditions. In addition, the Human Microbiome Project will help us understand the many genomes that our bodies depend on to live. Add to that continued sequencing of interesting comparative genomes and pathogen/vector genomes and you come up with a comprehensive plan for applying the science of genomics to human health; a springboard for better understanding of schizophrenia, autism, Parkinson's disease, and many more diseases.