The Genome Center recently published a paper entitled Aspects of coverage in medical DNA sequencing that develops a model for diploid sequence coverage using data from massively parallel sequencing platforms (454, Solexa, SOLiD). It uses a known yardstick, 8× BAC or WGS coverage with capillary sequencing, to establish the equivalent coverage for the new sequencing platforms. It turns out you need about 20× to 30× redundancy using these new platforms to obtain the equivalent amount of information as 10× coverage with capillary sequencing. The paper is published in an open access journal, BMC Bioinformatics, so enjoy.