The Genome Center's Elaine Mardis and Rick Wilson have just published a review article on cancer genome sequencing. The article focuses on the application of next-generation sequencing technologies to the study of cancer, covering structural variation studies using low coverage paired-end sequence data, targeted gene sequencing studies using PCR and Sanger sequencing, transcriptome sequencing using RNA-seq, and whole-genome sequencing, e.g., our AML publications. The article concludes with a brief discussion of the future of cancer sequencing and the functional genomics required to determine the role identified mutations play in cancer progression.