Politics, Information Technology, and Genomics

Breakin' 3: Genomic Variations

In the long awaited follow up to Breakin' and Breakin' 2, Ken Chen has released BreakDancer. As described in his Nature Methods article and a recent Genome Technology article, BreakDancer is not so much a movie as it is a bioinformatics program that can detect structural variation (insertions, deletions, inversions, and translocations) in genomes using paired-end read data. It can be used to detect structural variation in individual genomes, pools of genomes (like the low-coverage... Full Post

I'm not feeling well today

Yesterday the Senate Finance Committee, dominated by Democrats, failed to pass amendments to the health care bill that would have added a public health insurance option. It is worth noting why. Visit msnbc.com for Breaking News, World News, and News about the Economy Yes, Olbermann is practically hysterical, but his point should still be well taken. There are those who do not want a public option. They are not the American public, 65% of whom... Full Post

I am an influential blogger

John Travis contacted me to let me know about a recent article of his at ScienceInsider about the UK's plans to use DNA and isotope analysis to determine the nationality of people entering the country seeking asylum (Q&A). Such a program is truly unbelievable in its scope and irony. I can imagine the conversation at the border: "You want asylum from an overreaching government? Well let me bank your DNA. I promise I will only... Full Post

Sequencing primer

Ars Technica has the first in a (promised to be) series on DNA sequencing. This article just gets you through Sanger sequencing on a capillary electrophoresis instrument. Next-generation sequencing will be in the next one. Thanks to Scott Granneman for pointing out the article. Full Post

My secret past

Now everyone will know about my secret past before I joined The Genome Center: David Dooling: Gangbusters at the Genome Center. Bio-IT World also has a nice interview with Clive Brown of Oxford Nanopore, whom I first described as the most honest guy in all of next-gen sequencing. By the way, sorry for the extended absence, things have been crazy. Full Post