Comments for PolITiGenomics

Comment on SNP vs. SNP by What is the difference between an SNP and an SNV? - Quora

What is the difference between an SNP and an SNV? - Quora — Tue, 21 Feb 2012 22:39:18 +0000

[...] [1]:A SNV is a private mutation while a SNP is a mutation that is shared amongst a population[1] http://www.politigenomics.com/20…This answer .Please specify the necessary improvements. Edit Link Text Show answer summary [...]

Comment on Double standard by The Double Standard of Genomic Data Release and the Role of Incentives | Mike the Mad Biologist

Mon, 31 Oct 2011 00:27:27 +0000

[...] way of ScienceBlogling Daniel MacArthur, I came across this excellent post by David Dooling about, among other things, how different genome centers, based on size, have different release [...]

Comment on SNP vs. SNP by Types of Variations on a DNA Theme - Genomes Are Us

Types of Variations on a DNA Theme - Genomes Are Us — Fri, 12 Aug 2011 00:26:30 +0000

[...] polymorphisms (because sometimes they are more than a single base of the DNA). And I have also seen SNV becoming more widely used as more individuals are sequenced (single nucleotide [...]

Comment on The cost of doing sequencing by Cheral Canna

Cheral Canna — Sun, 07 Aug 2011 19:23:24 +0000

Coming in October from Xlibris Corp.
Genascent: The Human Genome Project in Plain Words
By C.J. Canna
This book was written for thoughtful members of the public. Many fields brush up against this science, finance, law, food, international relations, medicine, everything from agriculture thru zoology. This book discusses what a logical person might want to know before using or investing in the science.
The book includes particularly relevant journal articles explained here in common language.
You’ll be introduced to the ethical and legal questions that were buzzing around the Genome from the start. To engage the reader it includes funny stories collected over thirty years of a research career. To make the cut the stories had to tell something about the science that the reader should know; or show something about the research environment.
The author has written a trilogy of movie scripts named “Genascent: Footprints in Time” which tells the story of genetics from Gregor Mendel through1993; “Genascent II: the Living Code” covering the start-up through the completion of the sequence; and “Genascent III: So It Is Written” showing the impact the Genome has had in fighting disease.
The stories in this book could not be fit into the movies.

Comment on 454 Informatics by MC

MC — Wed, 29 Jun 2011 15:32:23 +0000

interesting read. we have just had our first run of 454 for human leukocyte antigens…still struggling with the data…

Comment on When stars align by Mona Sheikh

Mona Sheikh — Fri, 25 Feb 2011 14:58:25 +0000

David, can I use the image of the sequencing tile above in a chapter I am writing? Could you send me the original image too, if so? Let me know how I should credit you.

Thanks,
Mona

Comment on My talk at AGBT by Next-Generation Sequencing Informatics | Abhishek Tiwari

Next-Generation Sequencing Informatics | Abhishek Tiwari — Wed, 03 Nov 2010 09:55:48 +0000

[...] working at the Genome Center at Washington University in St. Louis. Here is a fantastic talk about next-generation sequencing informatics given by David during Advances in Genome Biology and Technology (AGBT) meeting. Presentation [...]

Comment on Striking at the root by Oliver

Oliver — Fri, 06 Aug 2010 21:21:45 +0000

Amen.

Comment on SNP vs. SNP by Ali

Ali — Mon, 12 Jul 2010 18:35:43 +0000

I think caution ought to be considered when describing polymorphisms—especially in lay discussions—as aberrations or even defects.

I’ve had discussions with medical personnel either using or condoning expressions like “THEIR DEFECTS” and “genetically deviant” when discussing children with idiopathic autism who were caused the clinical condition by vaccines. They even reference supposed genetic studies, which they seem to not realize are merely epidemiological and thus statistical studies a la the preferred applied science of medicine, to boost their characterizations.

They seem to not realize that research in basic science is showing that children with idiopathic autism evidently have functional polymorphisms—not defective genes—that are distributed throughout the population. They seem to have just more copies (copy number variants).

Comment on The cost of doing sequencing by dd

dd — Mon, 12 Jul 2010 15:42:51 +0000

Dr. DNA (if that is your real name), that is still not the whole cost: data transfer, storage on your system of the results, making sense of the variants, validation, project management, etc.